GEN

HCV Drug Therapy and the DNA Base Excision Repair System

The most frequent DNA lesions (8-oxoguanine, thymine glycol, dihydrothymine, dU) (De Bont and van Larebeke, 2014) are removed from the genome by the BER (Kim and Wilson, 2012) (Figure 1). This repair ...
Nature

Polymorphisms in the base excision repair pathway and graft-versus-host disease

Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality post-hematopoietic cell transplant (HCT). The pathophysiology of acute GVHD involves priming of immune response by pre ...
ascopubs.org

Association of base excision repair gene polymorphisms with response to chemotherapy of advanced non small-cell lung cancer in a Chinese population.

Effects of TKI on patients with non-small cell lung cancer of different stages: A meta-analysis. This is an ASCO Meeting Abstract from the 2018 ASCO Annual Meeting I. This abstract does not include a ...
ascopubs.org

Prognostic significance of nuclear excision (NER) and base excision (BER) DNA repair gene polymorphisms in esophageal cancer

ERCC1 mRNA expression and XRCC1 polymorphism as predictive factors for overall survival in gastric cancer patients receiving platinum based chemotherapy ...